Investigação

Início / Investigação / Artigos / Cholesterol-lowering effects of dietary blue lupin seeds (Lupinus angustifolius L.) in intact and ileo-rectal anastomosed pigs fed cholesterol-rich diet.

Cholesterol-lowering effects of dietary blue lupin seeds (Lupinus angustifolius L.) in intact and ileo-rectal anastomosed pigs fed cholesterol-rich diet.

Ano
2005
Abstract

The present study was undertaken to investigate the effect of cholesterol-enriched casein (CAS) and blue lupin seed (BL) diets on the cholesterol metabolism of intact (INT) and ileorectal anastomosed (IRA) pigs. For 3 weeks, four groups of six pigs were allocated to the treatments (CAS-INT, CAS-IRA, BL-INT, and BL-IRA). Diet-induced hypercholesterolemia was inhibited by the BL through a substantial decrease in plasma LDL-cholesterol. The BL also reduced liver esterified and total cholesterol, increased hepatic LDL receptor synthesis and HMG-CoA reductase activity, and stimulated intestinal bile acid reabsorption. The neutral sterol output was higher in BL- than in CAS- fed pigs. The bile acid output was lower in IRA than in INT pigs. Surgery also prevented steroid microbial transformation, but it did not influence plasma cholesterol levels. These results suggest that the hypocholesterolemic effect of the BL, compared with the CAS, is attributable to impaired intestinal cholesterol absorption, probably involving increased bile acid reabsorption and higher contents of dietary phytosterols, both factors that reduce the micellar solubilization of cholesterol. Furthermore, according to our data, the contribution of the large intestine to cholesterol metabolism is very weak.

Keywords

Pulses; Phytosterols; Dietary fiber; Hepatic enzymes; Steroid output; Steroid reabsorption.

Tipo de Artigo
Investigação
Tipo de Revisão
Internacional
Âmbito Geográfico
Internacional
Situação
Publicado
Referência

Martins, J; Riottot, M; Abreu, M; Viegas, A; Lança, M; Almeida, J; Freire, J; Bento, O (2005). Cholesterol-lowering effects of dietary blue lupin seeds (Lupinus angustifolius L.) in intact and ileo-rectal anastomosed pigs fed cholesterol-rich diets. Journal of Lipid Research, 46: 1526-1538.