Investigação

Início / Investigação / Artigos / Dietary raw peas (Pisum sativum L.) reduces plasma and hepatic cholesterol in intact and ileo‑rectal anastomosed pigs fed cholesterol‑rich diets.

Dietary raw peas (Pisum sativum L.) reduces plasma and hepatic cholesterol in intact and ileo‑rectal anastomosed pigs fed cholesterol‑rich diets.

Ano
2004
Abstract

Previous studies demonstrated the cholesterol‑lowering effect of dietary legumes (mainly soybeans) in animals and humans, but the mechanisms by which they exert this effect are not completely understood. The contribution of the hindgut to this hypocholesterolemic effect is also not well documented. The present work was undertaken to investigate the effect of cholesterol‑enriched (2.8 g/kg) casein (C) and raw pea seed (RP) diets on the cholesterol metabolism of intact (I) and ileorectal anastomosed (IRA) growing pigs. Four groups of 6 pigs were allocated to the treatments (C‑I, C‑IRA, RP‑I, and RP‑IRA pigs) for 3 wk. Plasma total cholesterol was lowered by the RP diet through a significant decrease in LDL cholesterol. The RP diet also decreased the hepatic concentration of esterified cholesterol and increased 3‑hydroxy‑3‑methylglutaryl CoA reductase activity and LDL receptor synthesis. The biliary total cholesterol and bile acid concentrations were greater in RP‑ than in C‑fed pigs. In addition, fecal bile acid output was higher in RP‑fed pigs. The cecum‑colon by‑pass inhibited cholesterol and ß‑sitosterol microbial transformation, lowered the bile acid output, and increased the primary to secondary bile acid output ratio, but its influence on cholesterolemia was negligible. These results suggest a hypocholesterolemic effect of the raw pea diet probably due to increased fecal bile acid output and an increased biliary bile acid concentration.

Palavras Chave

raw pea seeds; ileorectal anastomosis; pig; cholesterol metabolism; steroid output.

Tipo de Artigo
Investigação
Tipo de Revisão
Internacional
Âmbito Geográfico
Internacional
Situação
Publicado
Referência

Martins, J.; Riottot, M.; Abreu, M.; Lança, M.; Viegas, A.; Almeida, J.; Freire, J.; Bento, O. (2004). Dietary raw peas ( Pisum sativum L. ) reduces plasma and hepatic cholesterol in intact and ileo‑rectal anastomosed pigs fed cholesterol‑rich diets. Journal of Nutrition , 134: 3305‑3312.